Monday, November 26, 2012

Nintendo Wii U North American sales top 400K in first week

Nintendo of America president Reggie Fils-Aime says Wii U sales crested 400K units in its first week, according to internal sales data. That's just part of a 1.2 million hardware sales week that Nintendo's enjoyed across the past seven days -- which include the crucial Black Friday -- where the Wii saw 300K units sold, and portables dominated. Nintendo's 3DS sold 250K, while the aged DS moved 275K -- not too shabby for an eight-plus-year-old console! CNET snagged the data from Fils-Aime in a post-Wii U launch phone interview, where he characterized 3DS sales as continuing on a "record-setting pace" (now at more than 6 million units sold-in to North American retailers).

As for the seemingly paltry launch sales of the Wii U console -- 200K units shy of the original Wii's launch week -- Fils-Aime says it's a question of his company's ability to keep it in stores and not of lacking demand. "Retailers are also doing their best to get the product to store shelves. But as soon as product hits retail, they're selling out immediately," Fils-Aime explains. Without giving any concrete promises or timetables, he adds, "We are looking to have as much product into retail as possible."

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Source: Cnet

Source: http://www.engadget.com/2012/11/26/nintendo-wii-u-first-week-sales/

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Sunday, November 25, 2012

Holiday shopping season off to record start

FILE -In this Friday, Nov. 23, 2012, file photo, Black Friday shoppers pour into the Valley River Center mall for the Midnight Madness sale, in Eugene, Ore. U.S. shoppers hit stores and websites at record numbers over the four-day Thanksgiving weekend, according to a survey released by the National Retail Federation on Sunday. They were attracted by retailers' efforts to make shopping easier, including opening stores on Thanksgiving evening, updating mobile shopping applications for smartphones and tablets, and expanding shipping and layaway options. (AP Photo/The Register-Guard, Brian Davies)

FILE -In this Friday, Nov. 23, 2012, file photo, Black Friday shoppers pour into the Valley River Center mall for the Midnight Madness sale, in Eugene, Ore. U.S. shoppers hit stores and websites at record numbers over the four-day Thanksgiving weekend, according to a survey released by the National Retail Federation on Sunday. They were attracted by retailers' efforts to make shopping easier, including opening stores on Thanksgiving evening, updating mobile shopping applications for smartphones and tablets, and expanding shipping and layaway options. (AP Photo/The Register-Guard, Brian Davies)

FILE - In this Thursday, Nov. 22, 2012, file photo, shoppers wait on a check-out line in the Times Square Toys-R-Us store after doors were opened to the public at 8 p.m., in New York. U.S. shoppers hit stores and websites at record numbers over the four-day Thanksgiving weekend, according to a survey released by the National Retail Federation on Sunday. They were attracted by retailers' efforts to make shopping easier, including opening stores on Thanksgiving evening, updating mobile shopping applications for smartphones and tablets, and expanding shipping and layaway options. (AP Photo/John Minchillo)

(AP) ? If you make holiday shopping convenient, Americans will come in droves.

It's estimated that U.S. shoppers hit stores and websites at record numbers over the Thanksgiving weekend, according to a survey released by the National Retail Federation on Sunday. They were attracted by retailers' efforts to make shopping easier, including opening stores on Thanksgiving evening, updating mobile shopping applications for smartphones and tablets, and expanding shipping and layaway options.

All told, a record 247 million shoppers visited stores and websites over the four-day weekend starting on Thanksgiving, up 9.2 percent of last year, according to a survey of 4,000 shoppers that was conducted by research firm BIGinsight for the trade group. Americans spent more too: The average holiday shopper spent $423 over the entire weekend, up from $398 last year. Total spending over the four-day weekend totaled $59.1 billion, up 12.8 percent from 2011.

Caitlyn Maguire, 21, was one of the shoppers that took advantage of all the new conveniences of shopping this year. Maguire, who lives in New York, began buying on Thanksgiving night at Target's East Harlem store. During the two-hour wait in line, she also bought items on her iPhone on Amazon.com. On Friday, she picked up a few toys at Toys R Us. And on Saturday she was out at the stores again.

"I'm basically done," said Maguire, who spent about $400 over the weekend.

The results for the weekend appear to show that retailers' efforts to make shopping effortless for U.S. consumers during the holiday shopping season worked. Retailers upped the ante in order to give Americans more reasons to shop. Stores feared that consumers might not spend because of the weak job market and worries that tax increases and budget cuts will take effect if Congress fails to reach a budget deal by January.

Retailers, which can make up to 40 percent of their annual revenue in November and December, were hoping Thanksgiving openings and other incentives would help boost what's expected to be a difficult holiday shopping season. The National Retail Federation estimates that overall sales in November and December will rise 4.1 percent this year to $586.1 billion. That's more than a percentage point lower than the growth in each of the past two years, and the smallest increase since 2009, when sales were nearly flat.

Matthew Shay, president and CEO of the National Retail Federation, said retailers can be encouraged by the first weekend of the holiday shopping season.

"Retailers and consumers both won this weekend, especially on Thanksgiving," he said.

Here were the trends that emerged over the weekend:

? Online wave: According to comScore, which tracks online spending, online sales rose 26 percent to $1.04 billion on Black Friday compared with a year ago. On Thanksgiving, online sales rose 32 percent from last year to $633 million. And online sales on Black Friday were up 26 percent from the same day last year to $1.042 billion. It was the first time online sales on Black Friday surpassed $1 billion.

? Thanksgiving shopping: Many stores, including Toys R Us and Target, opened on Thanksgiving evening this year. No data is out yet about how much shoppers spent on that day, but it appears that consumers took advantage of the earlier start: According to the National Retail Federation's survey, the number of people who shopped on Thanksgiving rose 23.1 percent. That compares with a 3.1 percent increase for Black Friday.

Linda and James Michaels of Portland, Ore., were among those shopping on Thanksgiving. They hit up the big sales on the day and got everything they were hoping for that night.

They picked up remote control cars and some Mickey Mouse items on sale at Toys R Us. Then they went a few doors down to Target and scored the last Operation game on sale for $7. They were even able to pick up some pajamas and shoes along the way for the kids. In total they spent about $300.

"I felt lucky that I caught the deals and there was no craziness, no fighting," said Linda Michaels. "I was nervous."

ShopperTrak, which analyzes customer traffic at 40,000 U.S. stores, plans to release sales data for Thanksgiving later this week, but the firm is estimating that retailers generated $700 million in sales on the holiday.

? Black Friday flop: It appears that the Thanksgiving openings may have hurt sales on the day after.

Black Friday is still expected to be the biggest shopping day of the year, but sales on that day slipped to $11.2 billion, down 1.8 percent from last year, according to ShopperTrak. That's below ShopperTrak's estimate that Black Friday sales would rise 3.8 percent to $11.4 billion.

Karen MacDonald, a spokeswoman at Taubman Centers, which operates 28 malls across the country, said that Thanksgiving openings hurt business. Based on a sampling of 10 malls, sales growth was unchanged up to mid-single digits on Friday, and unchanged up to low single digit on Saturday.

"It was a different feeling," she said. "It was a good Black Friday, but I don't think it was great."

The disappointing sales on Black Friday may have been the result of shoppers like Miguel Garcia, a 40-year-old office coordinator.

"I can't deal with all that craziness," said Garcia, who was at a Target in the Bronx borough of New York City on Saturday. "Compared to what I saw on TV yesterday, this is so much more comfortable and relaxed. I can actually think straight and compare prices."

___

AP writers Rodrigue Ngowi in Watertown, Mass., Juan Carolos Llorca in El Paso, Texas, and Candice Choi in New York contributed to this report

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-11-25-US--Holiday%20Shopping/id-3049224b6ab249fe89c2f0b09bc92678

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Understanding the services provided by commercial truck financing ...

The lookup for commercial truck financing can be a overwhelming task to the uninformed customer. There is a myriad of commercial automobile loan companies and different kinds of commercial truck loans. If you are in need to have of utilized truck funding it is important to understand the companies offered by commercial truck financing.

A industrial truck bank loan is when the complete obtain value is financed. In most instances a down fee or trade-in car is required in order to obtain the financial loan, and the remainder of the acquire cost is paid off via the month-to-month repayments through the remainder of the expression. At the time of the purchase, taxes are paid out on the whole acquire value. A tax deduction may be claimed on a part of the desire paid throughout the calendar year. A deduction may also be produced for the depreciation of the motor vehicle, depending on the IRS depreciation schedules.

A industrial lease is an additional alternative in industrial truck funding and can be employed for utilized truck financing as properly. Based on the present financial scenario of the organization, several firms choose for a business automobile lease above a industrial truck bank loan. A lease is a outstanding way to finance a commercial truck or trailer. The finance conditions can variety from 24 months to 60 months and the acceptance approach is usually quicker than that of a bank loan generally an acceptance can be been given with in 24 hrs. In most situations a down charge is not required rather, some business creditors will request two month to month payments upfront. A lease does not show up on your stability sheets as a credit card debt, in which as a purchase will improve your liabilities.

An additional advantage of a industrial vehicle lease is the tax publish-off. Regular monthly repayments can be composed off in their entirety due to the fact they are tax deductible because the charge of the gear is considered as an operational price and not a liability.

Despite the fact that the lookup for commercial truck funding can be a tad overpowering, if you are armed with a general understanding of the providers offered by business car lenders, you will be nicely on your way to producing the proper selection for you company. Be confident to contemplate all of your choices as effectively as your company?s financial strengths and wants. There are commercial finance possibilities obtainable for all sorts of companies and organization credit score. If you do your due diligence, you will be ready to find the excellent suit for you and your company.

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  3. Commercial Truck Sales Locating Service
  4. Semi Truck Accident Victims Center Urges Family Members Of Victims Injured In A Semi Truck Truck Accident In Any US State To Call Them First For An Unequaled Response
  5. Commercial Loan Direct (CLD Capital) Renewing Its Caribbean Hotel & Resort Financing Program

Source: http://www.hugohosting.com/understanding-the-services-provided-by-commercial-truck-financing.html

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iPhone apps | iphone Finance apps Wolfram Capital Budgeting ...

When you need information about planning your long-term business investments, the Wolfram Capital Budgeting Professional Assistant will guide your decisions with calculators for depreciation, economic value added, rates of return, annuity values, and much more. This app provides accurate tools for computing what you need when it comes to capital budgeting, such as net present value (NPV), internal rate of return (IRR), and discounted cash flow (DCF).
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The Wolfram Capital Budgeting Professional Assistant is powered by the Wolfram|Alpha computational knowledge engine and is created by Wolfram Research, makers of Mathematica?the worlds leading software system for mathematical research and education.
The Wolfram Capital Budgeting Professional Assistant draws on the computational power of Wolfram|Alphas supercomputers over a 2G, 3G, 4G, or Wi-Fi connection.

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Source: http://apps.su/program/53505/wolfram-capital-budgeting-professional-assistant.html

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Saturday, November 24, 2012

Early start to Black Friday shopping frenzy

NEW YORK/CHICAGO (Reuters) - The shopping frenzy known as "Black Friday" kicked off at a more civilized hour, with shoppers welcoming decisions by retailers such as Target Corp and Toys R Us Inc to move their openings to Thursday night.

They also seemed to show little concern that the U.S. economy could be pushed over a "fiscal cliff," if a combination of tax hikes and spending cuts take effect in January. Some economists fear that could lead to another recession.

Yet the National Retail Federation expects sales during the holiday season to grow 4.1 percent this year.

The stakes are high for U.S. retailers, who can earn more than one-third of their annual sales and 40 to 50 percent of their profits during the holiday season, which generally starts with Black Friday.

"I think spending is better for the economy. I think you should spend. If you save all your money that will only make it worse," said Saiful Islam, 21, a New York accounting student who stood in line at Best Buy to purchase a variety of gadgets. "The line is bad, but the deals are good."

According to a Reuters/Ipsos poll, two-thirds of shoppers were planning to spend the same amount of money as last year or were unsure about plans, while 21 percent intended to spend less, and 11 percent planned to spend more.

"I definitely have more money this year," said Amy Balser, 26, at the head of the line outside the Best Buy store in the Mall of America in Bloomington, Minnesota. "I definitely don't think (the economy) has bounced back anywhere near as much as it needs to, but I see some improvement," she said.

While younger people like Balser generally said they felt comfortable spending money, those who are retired or close to it seemed to be more cautious.

Retired stockbroker Jack Connoly, 65, stood idly while his wife Mary tried on clothes at a Macy's in New York.

"Oh, we're spending less this year, whatever Mary says. Look at the stock market. If they don't do a deal on the debt by the end of December it's bye bye stock portfolio. We're being cautious," he said.

STARTING EARLY

Across the country, store lines were long - in the hundreds or more in many places - though the move toward earlier opening hours appeared to have helped. By sunrise on Friday, it was commonplace, even at large stores in the major cities, to find many more staffers than shoppers.

While the shift was denounced by store employees and traditionalists because it pulled people away from families on the U.S. Thanksgiving holiday, many shoppers welcomed the chance to shop before midnight or in the early morning hours.

"I think it's better earlier. People are crazier later at midnight," said Renee Ruhl, 52, a hotel worker, at a Target store in Orlando, Florida, where she was already heading to her car with an air hockey game in her shopping cart 2-1/2 hours before the chain opened last year.

Others were not as happy with an earlier Black Friday. A petition asking Target to "save Thanksgiving" had 371,606 supporters as of Thursday afternoon.

Some workers used the day to send a message.

OUR Walmart - a coalition of current and former Wal-Mart staff seeking better wages, benefits and working conditions - has staged months of protests outside stores and targeted "Black Friday" for action across the country.

In Chicago, four busloads of protesters, including some Walmart workers, showed up at a store on the city's South Side for a 7 a.m. protest. The crowd chanted "Walmart, Walmart you're no good, treat your workers like you should!" though their activities did not appear to deter shoppers.

Rosetta Brown, who has been with the company for 15 years and works at the Sam's Club store in Cicero, Illinois, took part in the protest and lamented how employees are treated now versus in the days of company founder Sam Walton.

"Sam Walton was a good man ... Walmart passed away with him," she said.

HIGH STAKES

The National Retail Federation said 147 million people would shop Friday through Sunday, when deals are at their most eye-catching - down from 152 million the same weekend last year.

Wal-Mart Stores Inc's U.S. discount stores, which have been open on Thanksgiving since 1988, offered some "Black Friday" deals at 8 p.m. on Thursday and special deals on certain electronics, like Apple Inc iPads, at 10 p.m.

The earlier hours lured people who had not braved the crowds before on Black Friday, said Jason Buechel, a senior executive in the retail practice of consultancy Accenture, in observing mall activity.

At Macy's in Herald Square in Manhattan, the line at the Estee Lauder counter was four deep shortly after its midnight opening. The cosmetics department's "morning specials" included free high-definition headphones with any fragrance purchase of $75 or more, and a set of six eye shadows for $10.

But for some people, cheap wasn't cheap enough - like the Macy's shopper who bought Calvin Klein shoes at 50 percent off but was not satisfied.

"I was hoping for deeper discounts," said Melissa Glascow, 35, a Brooklyn, New York, waitress who added she was saving her money for online discounts.

At the Target on Elston Avenue on Chicago's Northwest side - known as one of the highest-volume stores in the chain - the $25 Dirt Devil vacuum that normally goes for $39.99 was sold out, though there were still several large televisions available.

At 2 a.m. CST (0800 GMT), Mall of America was poised to beat the record number of shoppers - 217,000 - that came on the same day last year, according to mall spokesman Dan Jasper.

The day is also a test for retailers shifting strategies, like J. C. Penney Co Inc, which has been suffering from plunging sales as it moves away from coupons toward lower pricing and specialized boutiques within stores.

Amina Kebbeh, 18, of the Bronx, New York, was on line for the 6 a.m. EDT (1100 GMT) opening of Penney's Manhattan store. Others stood with her, though the line was relatively tame.

"If they remove the coupons, no one is eager to come," she said.

Some shoppers also faulted the chain's decision not to open in the wee hours, like Christian Alcantara, 18, who visited the store in the Elmhurst section of Queens, New York, and suggested it cost the retailer money.

"They should open earlier. I've been everywhere else and I've already shopped," he said.

(Additional reporting by Martinne Geller and Jochelle Mendonca in New York, Dhanya Skariachan in Bloomington, Minn., Paul Ingram in Tucson, Arizona, Jason McLure in Littleton, New Hampshire, and Barbara Liston in Orlando, Florida; Writing by Brad Dorfman and Ben Berkowitz; Editing by Nick Macfie, David Holmes and Jeffrey Benkoe)

Source: http://news.yahoo.com/black-friday-thursday-kicks-off-u-holiday-shopping-025954866--finance.html

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Analysis: Charges against BP employees test reach of U.S. statute

NEW YORK (Reuters) - Not all manslaughter charges are created equal. If they were, the U.S. Justice Department might have filed just 11 charges when it brought a criminal case against two BP Plc employees last week, one for each of the 11 deaths in the Deepwater Horizon disaster.

Instead, the government charged Robert Kaluza and Donald Vidrine, the two highest-ranking BP supervisors on board the rig in the hours before the 2010 disaster, with 11 counts of involuntary manslaughter and 11 counts of what's known as seaman's manslaughter.

The seaman's manslaughter statute was first passed by Congress in 1838 after a string of deadly steamboat accidents. The law, which has been modified multiple times since then, was intended to hold captains, engineers and pilots responsible for deaths attributable to their conduct.

The idea behind the law was that those operating a ship have a special responsibility toward passengers in their care. As The Wall Street Journal and others have noted, prosecutors face a lower bar in proving seaman's manslaughter than they do in ordinary manslaughter cases. Manslaughter charges generally require a finding of gross negligence; seaman's manslaughter does not.

The U.S. Court of Appeals for the 5th Circuit affirmed that distinction in a 2005 case, U.S. v. O'Keefe, which could be key precedent in the BP case. The O'Keefe case resulted in the seaman's manslaughter conviction of a tugboat captain whose wife drowned in the Mississippi River after the vessel capsized. At trial, the government introduced testimony indicating that the captain had ingested cocaine on the day of the accident. Prior to deliberations, the captain's lawyer asked that the jury be instructed that the government must show the accident was a result of "gross negligence," defined as "wanton or reckless disregard for human life."

U.S. District Judge Helen Berrigan in New Orleans disagreed, ruling that the statute requires only a finding of negligence, which she defined as an "omission to perform some duty" or a "violation of some rule or standard of care, which is made to govern and control one in the discharge of some duty." The 5th Circuit upheld her ruling and the captain's conviction.

But the 5th Circuit decision left unanswered the question of whether the government can assert seaman's manslaughter against Kaluza and Vidrine at all. The two are accused of failing to alert engineers onshore that BP's Macondo well was unstable and of accepting "illogical" explanations from members of the rig crew for the warning signs. In the indictment, prosecutors allege the two men violated the seaman's manslaughter statute by engaging in "negligence" and "inattention" to their duties.

Here's what the seaman's manslaughter statute says: "Every captain, engineer, pilot or other person employed on any steamboat or vessel, by whose misconduct, negligence or inattention to his duties on such vessel the life of any person is destroyed ... shall be fined under this title or imprisoned not more than ten years, or both."

Vidrine and Kaluza were not captains or engineers of the Deepwater Horizon. The two have been described by investigators, including those who wrote the "Chief Counsel's Report" on the Deepwater disaster, as "well site leaders." According to the report, well site leaders served as BP's "eyes and ears, and made important decisions regarding the course of drilling operations." As the litigation against Vidrine and Kaluza progresses, a judge may have to decide whether "well site leaders" should fall within the "other person" category covered by the seaman's manslaughter statute.

A search of the database of legal research service Westlaw shows the statute has rarely been used in the last decade, and when it has, it has mostly been against defendants who were responsible for navigating a vessel. In the case of the convicted tugboat captain, neither the trial judge nor the 5th Circuit addressed who is covered under the statute, but Judge Berrigan emphasized the statute's purpose of holding responsible those in charge of navigation.

"In light of the unique dangers of maritime travel, the vulnerability of passengers on board such vessels and the voluntary nature of employment or ownership, it is reasonable to impose on such crews a heightened degree of care with the parallel lower threshold for criminal liability," she wrote.

It may be a long shot for Vidrine and Kaluza to argue that the seaman's manslaughter statute does not apply to them, but it's probably one worth taking. Vidrine counsel Robert Habans of Habans & Carriere and Kaluza lawyer Shaun Clarke of Gerger & Clarke both declined to comment. They have previously said their clients are innocent and have been unfairly targeted by the government.

(Reporting by Andrew Longstreth; Editing by Ted Botha and John Wallace)

Source: http://news.yahoo.com/analysis-charges-against-bp-employees-test-reach-u-201413220--finance.html

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Scientists describe elusive replication machinery of flu viruses

Friday, November 23, 2012

Scientists at The Scripps Research Institute (TSRI) have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to "see" one of influenza's essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus's vulnerabilities that are sure to be of interest to drug developers.

The report, which appears online in Science Express on November 22, 2012, focuses on influenza's ribonucleoprotein (RNP). RNPs contain the virus's genetic material plus the special enzyme that the virus needs to make copies of itself.

"Structural studies in this area had stalled because of the technical obstacles involved, and so this is a welcome advance," said Ian A. Wilson, the Hansen Professor of Structural Biology at TSRI and senior author of the report with TSRI Professors of Cell Biology Bridget Carragher and Clint Potter. "The data from this study give us a much clearer picture of the flu virus replication machinery."

Unveiling the Mystery of RNPs

At the core of any influenza virus lie eight RNPs, tiny molecular machines that are vital to the virus's ability to survive and spread in its hosts. Each RNP contains a segment?usually a single protein-coding gene?of the RNA-based viral genome. This viral RNA segment is coated with protective viral nucleoproteins and has a structure that resembles a twisted loop of chain. The free ends of this twisted loop are held by a flu-virus polymerase enzyme, which handles the two central tasks of viral reproduction: making new viral genomic RNA, and making the RNA gene-transcripts that will become new viral proteins.

Aside from its importance in ordinary infections, the flu polymerase contains some of the key "species barriers" that keep, for example, avian flu viruses from infecting mammals. Mutations at key points on the enzyme have enabled the virus to infect new species in the past. Thus researchers are eager to know the precise details of how the flu polymerase and the rest of the RNP interact.

Getting those details has been a real challenge. One reason is that flu RNPs are complex assemblies that are hard to produce efficiently in the lab. Flu polymerase genes are particularly resistant to being expressed in test cells, and their protein products exist in three separate pieces, or subunits, that have to somehow self-assemble. Until now, the only flu RNPs that have been reproduced in the laboratory are shortened versions whose structures aren't quite the same as those of native flu RNPs. Researchers also are limited in how much virus they can use for such studies.

The team nevertheless managed to develop a test-cell expression system that produced all of the protein and RNA components needed to make full-length flu RNPs. "We were able to get the cells to assemble these components properly so that we had working, self-replicating RNPs," said Robert N. Kirchdoerfer, a first author of the study. Kirchdoerfer was a PhD candidate in the Wilson laboratory during the study, and is now a postdoctoral research associate in the laboratory of TSRI Professor Erica Ollmann Saphire.

Kirchdoerfer eventually purified enough of these flu RNPs for electron microscope analysis at TSRI's Automated Molecular Imaging Group, which is run jointly by Carragher and Potter.

Never Seen Before

The imaging group's innovations enable researchers to analyze molecular samples more easily, in less time, and often with less starting material. "We were able, for example, to automatically collect data for several days in a row, which is unusual in electron microscopy work," said Arne Moeller, a postdoctoral research associate at the imaging group who was the other first author of the study.

Electron microscopes make high-resolution images of their tiny targets by hitting them with electrons rather than photons of light. The images revealed numerous well-defined RNP complexes. To Moeller and his colleagues' surprise, many of these appeared to have new, partial RNPs growing out of them. "They were branching?this was very exciting," he said.

"Essentially these were snapshots of flu RNPs being replicated, which had never been seen before," said Kirchdoerfer. These and other data, built up from images of tens of thousands of individual RNPs, allowed the team to put together the most complete model yet for flu-RNP structure and functions. The model includes details of how the viral polymerase binds to its RNA, how it accomplishes the tricky task of viral gene transcription, and how a separate copy of the viral polymerase assists in carrying out RNP replication. "We're now able to take a lot of what we knew before about flu virus RNP and map it onto specific parts of the RNP structure," said Kirchdoerfer.

The new flu RNP model highlights some viral weak points. One is a shape-change that a polymerase subunit?which grabs viral RNA and feeds it to the polymerase's active site on a second subunit?has to undergo during viral gene transcription. Another is key interaction between the polymerase and viral nucleoproteins. Flu RNPs are long and flexible, curving and bending in electron microscope images; and thus the structural model remains only modestly fine-grained. "You wouldn't be able to design drugs based on this model alone," said Kirchdoerfer, "but we now have a much better idea of how flu RNPs work, and that does suggest some possibilities for better flu drugs."

###

Scripps Research Institute: http://www.scripps.edu

Thanks to Scripps Research Institute for this article.

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Source: http://www.labspaces.net/125443/Scientists_describe_elusive_replication_machinery_of_flu_viruses

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